THE FACTS
• Total U.S. prescription drug expenditures are projected to hit over $497.5 billion by 2016. This is compared to $200.7 billion spent on U.S. prescriptions in 2005—a 148% increase. 
• $200.7 billion was spent on prescription drugs in the U.S. in 2005, up from the $179.2 billion spent just two years before.
• Prescription drug expenses in the U.S. account for approximately 20% of total health expenses
• Employee healthcare is soaring faster than any other business cost, and prescription drug costs increase faster than any other health care expense.
• The majority of the top 25 grossing prescriptions are not lifesaving, and many of them were not even in existence a decade ago.
• 80.8% of the cost of employee healthcare was paid for out-of-pocket or by private insurance.
• Adverse drug effects (death or debility) have more than doubled in the last decade, as have FDA recalls of previously approved drugs.
• Adverse drug events injure an estimated 1.5 million people each year, at a cost of approximately $3.5 billion. These numbers do not factor in lost wages, productivity, or additional healthcare costs incurred as a result of these injuries.
• Adverse drug reactions are known to be responsible for between 3 percent and 12 percent of hospital admissions, and fatal drug reactions account for about 5 percent of deaths of those patients in hospitals in the United States. Adverse Drug Reactions are estimated to account for the seventh most common cause of death.
• Drugs are routinely prescribed for conditions for which the drug was not FDA approved, called “off label” prescribing.
• Three of the top five drugs prescribed to dependent children were optional with no clear medical indication, and amounted to $1.3 billion in costs.
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